RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
miR-155-5p
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
RT-PCR; dual-luciferase reporter assay
Target
C-SKI
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
Apigenin attenuates TGF-beta1-stimulated cardiac fibroblast differentiation and extracellular matrix production by targeting miR-155-5p/c-Ski/Smad pathway
Year
2021
Function
"These findings suggested that apigenin could inhibit the differentiation and extracellular matrix production in TGF-beta1-stimulated CFs, and its mechanisms might partly be attributable to the reduction of miR-155-5p expression and subsequent increment of c-Ski expression, which might result in the inhibition of Smad2/3 and p-Smad2/3 expressions."
RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
mir-155-5p
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
RT-PCR; dual-luciferase reporter assay
Target
C-SKI
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
Apigenin attenuates TGF-beta1-stimulated cardiac fibroblast differentiation and extracellular matrix production by targeting miR-155-5p/c-Ski/Smad pathway
Year
2021
Function
"These findings suggested that apigenin could inhibit the differentiation and extracellular matrix production in TGF-beta1-stimulated cardiac fibroblasts (CFs), and its mechanisms might partly be attributable to the reduction of miR-155-5p expression and subsequent increment of c-Ski expression, which might result in the inhibition of Smad2/3 and p-Smad2/3 expressions."